Many cluster policies and initiatives exist in SEE area: a prioritization and concentration of the different actions towards creating world class clusters is a strategic challenge to fulfil EU competitiveness objectives. Regional innovation policies in target regions demonstrated lack of efficiency in identifying priorities and forms of collaboration between regions.There is also a need for fact - based cluster policies: comparable data on cluster-specific framework conditions and methods for evaluating effectiveness lacking.Policy makers need to better assess impact of clusters on competitiveness and innovation. This can lead the SEE regions to become innovation hubs and clusters can be powerful catalysts in this process. ClusterPoliSEE project, funded under the 3rd strategic call for proposal and involving 24 partners of SEE Europe area,  answers to the identified needs thorugh the improvement of capacity of regional policy makers to confront, prevent and anticipate change, developing smart specialization strategies for cluster improvement, thus accelerating differentiation and structural change towards a knowledge-based economy in which there is a place for all SEE regions to position themselves.